HUMAN PAPILLOMA VIRUS INFECTION (VENEREAL WARTS) – DEFINITION
Warts are caused by infection with human papilloma virus (HPV). So far more than 50 HPV genotypes have been described.
Several genotypes are well characterised as occurring mainly in the genital tract causing various lesions including venereal warts or condylomata acuminata and microscopic changes in the epithelium of the cervix, vagina, vulva, penis or rectum. There is a close relationship between cervical HPV infection and cervical intraepithelial neoplasia (CIN), in situ (CIS) and invasive squamous cell carcinoma. HPV genotypes 6 and 11 are associated predominantly with benign lesions; types 16, 18, 31 and 33 predominate in the more dysplastic lesions and in squamous cell carcinoma.
Genotypes 1, 2, 3,4 and 10 are associated with common skin warts and rarely infect the anogenital region.
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